Combination antifungal therapy in treatment of murine pulmonary mucormycosis: roles of quinolones and azoles.

A Review of Antifungals and their Mono- and Combination- therapy in the Treatment of Invasive Fungal Infections

Invasive fungal infections with high mortality rate are a growing health concern in hospitals and medical centers. The infection usually occurs in people with compromised immune systems. The purpose of this paper is a review of the most commonly prescribed antifungal drugs for invasive fungal diseases. Antifungals consist of the four main groups; polyenes, azoles, echinocandins and DNA an...

Combination antifungal therapy without craniotomy in an immunocompromised patient with rhino-orbito-cerebral mucormycosis: A case report

موکورومایکوز با تظاهر اوتیت مدیای حاد

Introduction: Mucormycosis is a rare, fatal infection which mainly affects the patients with diabetes or immunodeficiency. Various clinical forms of the disease include rhinocerebral, pulmonary, cutaneous, gastrointestinal, and disseminated infection. The aim of this study was to report a rare case of mucormycosis involving middle ear.Case Report: A 22-year-old female patient with a history...

Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients

INTRODUCTION Because of the high mortality of invasive fungal infections (IFIs), appropriate exposure to antifungals appears to be crucial for therapeutic efficacy and safety. MATERIALS AND METHODS This review summarises published pharmacokinetic data on systemically administered antifungals focusing on co-morbidities, target-site penetration, and combination antifungal therapy. CONCLUSIONS...

Primary Cutaneous Mucormycosis of the Neck:A CaseReport with Review of Literature

Background: Cutaneous mucomycosis is an invasive fungal infection that usually develops in the immunodeficient patients. Although it also occurs in cases without underlying disease. So far in Iran and the world, primary cutaneous mucormycosis of the neck without predisposing factor has not  been reported. Materials and Methods: In this case,we present a 51 years old patient with progressive nec...